DESIGN AND EVALUATION OF INSULIN LOADED BIO-FILMS FOR TRANS SOFT-PALATAL TO BRAIN DELIVERY


N.V.Satheesh Madhav, Pranshu Tangri

ABSTRACT:
The current objective of our study was the formulation and evaluation of insulin loaded trans-soft palatal bio-films for treating alzhiemer’s disease. A novel bio-film former was isolated from the fruit pulp of Artocarpus heterophyllus by our previously published method. The bio-films were aimed at delivery through the soft palate for brain targeting. The isolated bio-material was screened for filmability by forming films of the isolated bio-material by solvent casting method and mucoadhesivity by shear stress method. Six(FJ1-FJ6) formulations were prepared by varying the polymer: drug ratios(1:1,1:2,1:3,1:4,1:5,1:6) by solvent casting method. Insulin was used as the model drug as research reveals its stimulating effect on cognition. The formulated films showed uniform surface ph, thickness, weight variation and acceptable content uniformity, folding endurance, moisture uptake, moisture content, tensile strength. Mucoaretention studies were performed by M.S. apparatus and Park and Robinson method. The formulation FJ3 was found to be the best formulation on the basis of mucoretention and in-vitro diffusion study. It showed mucoretention of more than 6 hours, t50% and t80% of more than 6hours and 10 hours respectively. A smart conclusion was drawn that the isolated bio-polymer can be used as an bio-film former for formulating various pharmaceutical preparations.
KEY WORDS: Artocarpus heterophyllus, insulin, bio-material, Alzheimers disease.