HEPATOTOXIC EFFECT OF CHARACTERIZED SILVER NANOPARTICLE


Jyoti Prakash Pani, S .P .Mishra, R.S. More, Sanjay Singh, Royana Singh

ABSTRACT
Silver nanoparticles (NPs), is widely used in the manufacture of various types of consumer products.  It is widely applied in textile industries, optics, electronics, catalysis, magnetic and medical fields, which includes therapeutic and diagnostic. It has antibacterial and antifungal property. It belongs to novel types of materials but pose potential risks to human as well as animal health. It negatively affects mice at higher dose when repeatedly induced through oral gavages. It creates toxicity in target organ liver predominantly by accumulating inside it and enhances oxidative stress in vital organs by over production of ROS in cell and depletion of antioxidant enzyme level in tissue. The effect of Ag-NPs on hepatic Catalase and glutathione (GSH) levels were variable in different treated groups compared with the control.

Keywords : Magnetic stirring and cooling method, smaller size silver nanoparticle toxicity, oral gavages exposure.