PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES ON ZINGIBER ZERUMBET HYDRO-ALCOHOLIC EXTRACT FOR ANTICONVULSANT ACTIVITY


Lincy Joseph, Mathew George, Sreelakshmi.R

ABSTRACT
Aim- The aim of this study is to evaluate anticonvulsant activity and to determine the Total flavonoid content (TFC), Total tannin, Total carbohydrates in hydroalcoholic extract of Z. zerumbet.
Materials and methods- Plant materials are collected from puthuppally.Hydroalcoholic extract was screened for different phytochemical constituents. Acute toxicity studies are done according to OECD guidelines. Hydro alcoholic extracts were screened for anticonvulsant activity(induced by PTZ) in Wistar Albino rats.Quantified total content of carbohydrates (phenol-sulfuric acid method), tannins and flavonoids.
Result – Hydroalcoholic extract of Zingiber zerumbet shows significant anticonvulsant activity compard to control.Presence of carbohydrate,flavonoid,tannins and terpenoids were identified in the extract.
Conclusion– The result suggest that the hydro-alcoholic extract of zingiber zerumbet rhizome contains some active principles which may possess significant anticonvulsant activity.

Key words- Zinginer zerumbet, PTZ-Pentyene tetrazole,hydro-alcoholic extract