SYNTHESIS AND CHARACTERIZATION OF TRANSITION METAL COMPLEXES WITH A TETRAAZA MACROCYCLIC LIGAND: INHIBITORY ACTIVITY AGAINST SOME FUNGI


Anil Kumar, Sulekh Chandra

ABSTRACT
Co(II), Ni(II) and Cu(II) complexes were synthesized with a tetraaza macrocyclic ligand i.e. 1,5-dioxo-9,10-diaza-3,ol-tribenzo-(7,6,10,11,14,15) peptadecane. The ligand was characterized on the basis of elemental analysis, IR, 1H NMR, ESI Mass studies while the complexes were characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, IR, electronic and EPR spectral studies. The molar conductance values of the complexes indicate the non-electrolyte nature  and the complexes may be formulated as  [ M(L)X2], where M = Co(II), Ni(II), Cu(II) and X=  Cl-  and NO3-. On the basis of spectral studies, an octahedral geometry has been assigned for the Co(II) and Ni(II) complexes, whereas tetragonal  geometry was found for Cu(II) complexes. In vitro antifungal activity was evaluated for the ligand and its complexes against some pathogenic fungi to assess their growth inhibiting potential.

Keywords: IR and NMR spectra, Co  Ni Cu Antifungal screening.