EFFECT OF ASPIRIN IN THE KIDNEY OF WISTAR ALBINO RATS- A HISTOMORPHOLOGICAL STUDY


Awasthi JR, Pandey N, Yadav G, Shrestha S, Jha CB

ABSTRACT

Background: Aspirin is the acetylated form of the Salicylic acid. Salicylic acid has been used since ancient times to provide pain relief and treat inflammatory conditions. It is a phenolic compound present in plants, where it plays a central role in the development of local and systemic resistance to pathogen infection. Humans and animals obtain SA mainly from daily foods, fruits, and vegetables.

Objectives: To determine the effect of aspirin in the kidney of Wistar albino rat.

Materials and Methods: Sixty rats were randomly divided into equal two groups. Group I (control) was injected (i.p.) 1ml of saline per day. Group II was given 100 mg/kg aspirin daily i.p. All groups were treated over a period of eight consecutive days and on 9th day; rats were sacrificed. Kidney slides were prepared microscopic examination. Independent t-test was used for data analysis.

Results: Examination of renal cortex from the both control group and aspirin treated rats showed normal parenchyma. However, in the latter group only few tubules showed the loss of brush border and necrosis but they were not desquamated. The oculometric analysis of renal tubules showed that diameter of the proximal and distal convoluted tubules, and renal corpuscles were similar in both the group. However, the diameter of glomerulus was significantly increased and the renal space was significantly reduced in aspirin treated rats compared to normal.

Conclusion: Thus, aspirin shows minimal renal toxic effect, however, all the histo-architecture of the kidney was normal.

Keywords: Aspirin, Nephrotoxicity, Kidney, Wistar albino rats