CORRELATION OF LIPID PROFILE AND GLYCEMIA IN ORAL PRECANCEROUS LESION AND CONDITIONS


Mujoo S., Shashikant MC., Dubey A., Dubey A.

ABSTRACT

Background: Lipids are major cell membrane components essential for various biological functions including

cell growth and division of normal and malignant tissues. Low lipid values in cancer, precancer lesion and condition may be because of lipid peroxidation as there is greater utilization of lipids including total cholesterol (TC) and triglycerides (TG) for new membrane biogenesis. Cells fulfill these requirements either from circulation or by synthesis through the metabolism.

Objective: The present study was aimed at elucidating alteration in serum lipid profile and blood glucose level in Oral Precancerous patients.

Method: A total sample size of 90 subjects were chosen , 30 were diagnosed with leukoplakia and 30 with OSMF and compared with 30 control group. The serum triglycerides were estimated by GPO-PAPA END point Assay method; total cholesterol by CHOD-PAP and HDL cholesterol by PEG-CHOD-PAP, End point assay method with lipid clearing factors. The LDL and VLDL levels were calculated using Friedewalds equation.

Result: This study showed that two parameters TC, TG of lipid profile were significantly reduced in oral Precancerous group cases as compared to age and sex matched healthy controls. There was no significant change in LDL, VLDL, HDL, FBS, and PPBS.

Conclusion: Lower serum TC, TG may indicate with increased risk of precancer occurrence. It may be used as an adjunctive tool in evaluation of oral cancer and pre cancer along with other parameters of biochemical markers.

Keywords: Total Cholesterol, Triglycerides, Lipoproteins, Lipid peroxidation